I put this issue in the Pérez checklist, but it's not really a "must have" item. Similarly like OFFICIAL TEEN TITANS INDEX #5 is not crucial to your collection, but it is worth a small mention.
FANTASTIC FOUR #500 (Director's Cut Edition) is the first time that a comic book has extra material, like the popular "Director's Cut/Special Edition" DVDs. There's 15 pages of extra material: "Deleted Scenes", sketch designs, "Outakes", Fred Hembeck's "Fantastic Five... Hundred, That Is!!", process of putting a comic book together, Stan Lee's original synopsis for FF #1, and a "Printography".
The Printography reprints all previous 499 covers of the Fantastic Four, over three pages. Obviously in order to fit all the covers the reprints of each cover is about 3 by 5 cm.
Here is a small portion of the Printography:
George Pérez did the following FF covers:
Fantastic Four #183 (CP)
Fantastic Four #184 (CP, IP)
Fantastic Four #185 (CP, IP)
Fantastic Four #186 (CP, IP)
Fantastic Four #187 (CP, IP)
Fantastic Four #188 (CP, IP)
Fantastic Four #191 (CP, IP)
Fantastic Four #192 (CP, IP)
Fantastic Four #194 (CA)
Fantastic Four #195 (CP)
Fantastic Four #196 (CP)
Fantastic Four #197 (CP)